Inhibition of IL34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in chronic neurodegeneration
Juliane Obst, Emilie Simon, María Martín‐Estebané, Elena Pipi, Liana M. Barkwill, Ivette González-Rivera, Fergus Buchanan, Alan R. Prescott, Dörte Faust, Simon G. Fox, Janet Brownlees, Debra L. Taylor, Victor Hugh Perry, Hugh Norman Nuthall, Peter J. Atkinson, , Diego Gómez‐Nicola
This study evaluates IL-34 inhibition as a strategy to reduce microglial proliferation in prion disease, showing tissue-selectivity and reduced side effects compared to CSF1R inhibition.
Frontiers in Immunology · Oct 8, 2020Peer-reviewedNeuroscience