Diego Gómez‐Nicola

This study shows that low-grade systemic inflammation accelerates Alzheimer's-like pathology by promoting microglial turnover and disease-associated microglia through the CSF1R pathway.

This study investigates microglial colonisation during brain development, showing clonal expansion of proliferative progenitors and an allometric scaling of microglia density.

This study examines microglial dynamics across the human lifespan using postmortem tissues and RNAseq data, revealing novel developmental patterns linked to neurodevelopmental milestones.

This study shows that excessive microglial proliferation in Alzheimer's disease leads to replicative senescence and disease-associated microglia, contributing to Aβ pathology.

The paper examines age-related changes in oligodendrocyte precursor cells (OPCs) in APP/PS1 mice, showing accelerated dystrophy and decay compared to non-transgenic controls.

This study evaluates IL-34 inhibition as a strategy to reduce microglial proliferation in prion disease, showing tissue-selectivity and reduced side effects compared to CSF1R inhibition.

This study shows that synaptic silencing reduces oligodendrocyte precursor cell density and complexity in adult mouse hippocampus.

The paper shows an age-dependent decline in GluN2B-containing NMDA receptors in human cortical synapses, potentially contributing to age-related cognitive decline.