María Martín‐Estebané

Maternal Immune Activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells

This study identifies translational dysregulation and MAP2 phosphorylation differences in neural stem cells from offspring exposed to maternal immune activation.

Spatiotemporal dynamics of human microglia are linked with brain developmental processes across the lifespan

This study examines microglial dynamics across the human lifespan using postmortem tissues and RNAseq data, revealing novel developmental patterns linked to neurodevelopmental milestones.

Replicative senescence dictates the emergence of disease-associated microglia and contributes to Abeta pathology

This study shows that excessive microglial proliferation in Alzheimer's disease leads to replicative senescence and disease-associated microglia, contributing to Aβ pathology.

Inhibition of IL34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in chronic neurodegeneration

This study evaluates IL-34 inhibition as a strategy to reduce microglial proliferation in prion disease, showing tissue-selectivity and reduced side effects compared to CSF1R inhibition.