Author

Eric H. Karran

AbbVie (United States)ORCID 0000-0002-6782-5213Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Alberto Serrano‐PozoiD· 3 shared Astrid WachteriD· 3 shared Bradley T. HymaniD· 3 shared Maya E. WoodburyiD· 3 shared Robert V. TalanianiD· 3 shared Sudeshna DasiD· 3 shared Zhaozhi LiiD· 3 shared Aicha Abdourahman· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Alberto Serrano‐PozoORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Distinct Transcriptomic Responses to A beta plaques, Neurofibrillary Tangles, and APOE in Alzheimer's Disease

Sudeshna Das, Zhaozhi Li, Astrid Wachter, Srinija Alla, Ayush Noori, Aicha Abdourahman, Joseph A. Tamm, Maya E. Woodbury, Robert V. Talanian, Knut Biber, Eric H. Karran, Bradley T. Hyman, Alberto Serrano‐Pozo

The paper examines transcriptomic changes in Alzheimer's disease brain regions associated with Aβ plaques, tangles, and APOE ε4, finding distinct gene expression patterns linked to neuroinflammation and neuronal dysfunction.

Alzheimer s & Dementia · Jul 17, 2023Peer-reviewedNeuroscience

Endothelial Cells are Heterogeneous in Different Brain Regions and are Dramatically Altered in Alzheimer's Disease

Annie G. Bryant, Zhaozhi Li, Rojashree Jayakumar, Alberto Serrano‐Pozo, Benjamin Woost, Miwei Hu, Maya E. Woodbury, Astrid Wachter, Gen Lin, Taekyung Kwon, Robert V. Talanian, Knut P. H. Biber, Eric H. Karran, Bradley T. Hyman, Sudeshna Das, Rachel E. Bennett

The paper analyzes endothelial cell heterogeneity across brain regions in Alzheimer's disease using single nucleus RNAseq, revealing region-specific gene expression changes and disease-related transcriptomic alterations.

Journal of Neuroscience · May 19, 2023Peer-reviewedNeuroscience

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer's disease

Alberto Serrano‐Pozo, Zhaozhi Li, Maya E. Woodbury, Clara Muñoz‐Castro, Astrid Wachter, Rojashree Jayakumar, Annie G. Bryant, Ayush Noori, Lindsay A. Welikovitch, Miwei Hu, Karen Zhao, Fan Liao, Gen Lin, Timothy Pastika, Joseph A. Tamm, , Sudeshna Das

This study uses single-nucleus RNA-sequencing to analyze astrocyte transcriptomic changes across the spatiotemporal progression of Alzheimer's disease, revealing gene expression trajectories and heterogeneity.

bioRxiv · Dec 3, 2022 · PreprintNeuroscience

Inhibition of IL34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in chronic neurodegeneration

Juliane Obst, Emilie Simon, María Martín‐Estebané, Elena Pipi, Liana M. Barkwill, Ivette González-Rivera, Fergus Buchanan, Alan R. Prescott, Dörte Faust, Simon G. Fox, Janet Brownlees, Debra L. Taylor, Victor Hugh Perry, Hugh Norman Nuthall, Peter J. Atkinson, , Diego Gómez‐Nicola

This study evaluates IL-34 inhibition as a strategy to reduce microglial proliferation in prion disease, showing tissue-selectivity and reduced side effects compared to CSF1R inhibition.

Frontiers in Immunology · Oct 8, 2020Peer-reviewedNeuroscience