Author

Juliane Obst

Southampton General HospitalORCID 0000-0001-9534-8488Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Diego Gómez‐NicolaiD· 2 shared María Martín‐EstebanéiD· 2 shared Adrián Olmos‐Alonso· 1 shared Alan R. PrescottiD· 1 shared Carol A. Routledge· 1 shared Claire MartiniD· 1 shared Daniel Thomas· 1 shared David A. MenassaiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersNeuroscience

Diego Gómez‐NicolaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintJul 2, 2025

SHIP1 regulates TREM2 signalling and macrophage functions in a hiPSC-derived model

Claire Martin, Juliane Obst, Shania Ibarra…·Emma Mead

This study shows that SHIP1 regulates TREM2 signaling and macrophage functions in hiPSC-derived macrophages, affecting inflammation and phagocytosis.

DOI 10.1101/2025.07.02.662745

humanproteomics

NeuroscienceCell ReportsPeer-reviewedJun 1, 2021

Replicative senescence dictates the emergence of disease-associated microglia and contributes to Abeta pathology

Yanling Hu, Gemma L. Fryatt, Mohammadmersad Ghorbani…·Diego Gómez‐Nicola

This study shows that excessive microglial proliferation in Alzheimer's disease leads to replicative senescence and disease-associated microglia, contributing to Aβ pathology.

298 citationstop 1%

humanbulk RNA-seq

NeuroscienceFrontiers in ImmunologyPeer-reviewedOct 8, 2020

Inhibition of IL34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in chronic neurodegeneration

Juliane Obst, Emilie Simon, María Martín‐Estebané…·Diego Gómez‐Nicola

This study evaluates IL-34 inhibition as a strategy to reduce microglial proliferation in prion disease, showing tissue-selectivity and reduced side effects compared to CSF1R inhibition.

33 citations

mouseexperimental assay