Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection
Jin Wei, Mia Madel Alfajaro, Ruth E. Hanna, Peter C. DeWeirdt, Madison S. Strine, William J. Lu-Culligan, Shang‐Min Zhang, Vincent R. Graziano, Cameron O. Schmitz, Jennifer Chen, Madeleine C. Mankowski, Renata B. Filler, Victor Gasque, Fernando de Miguel, Huacui Chen, , Craig B. Wilen
A genome-wide CRISPR screen with SARS-CoV-2 recovers ACE2 and Cathepsin L and nominates SWI/SNF, TGF-beta signalling and HMGB1 as pro-viral; pathway inhibitors blocked virus-induced death.
bioRxiv · Jun 16, 2020 · PreprintGenetics