Author

Brett D. Lindenbach

Yale UniversityORCID 0000-0003-4880-1213Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Brett D. Lindenbach1 paper

Biology Disciplines

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Biochemistry· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

Craig B. WileniD· 2 shared Laura AbriolaiD· 2 shared Mia Madel AlfajaroiD· 2 shared Yulia V. SurovtsevaiD· 2 shared Benhur LeeiD· 1 shared Cameron O. SchmitziD· 1 shared David van DijkiD· 1 shared Fernando de Miguel· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersMolecular Biology

Craig B. WilenORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 25, 2024

The hyperphosphorylation of SARS-CoV-2s nucleocapsid protein by GSK-3 involves a complex and redundant priming mechanism

Song Chen, Zunyu He, Jean E. Kanyo…·Ya Ha

This study reveals that SARS-CoV-2 nucleocapsid protein hyperphosphorylation by GSK-3 involves a complex, cooperative priming mechanism rather than simple sequential phosphorylation.

DOI 10.1101/2024.05.25.595913

virusproteomics

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Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewedJun 14, 2021

Restriction of SARS-CoV-2 Replication by Targeting Programmed -1 Ribosomal Frameshifting In Vitro

Yu Sun, Laura Abriola, Rachel O. Niederer…·Junjie U. Guo

This study identifies merafloxacin as a -1 PRF inhibitor that impedes SARS-CoV-2 replication in vitro.

131 citationstop 1%

experimental assaydrug response / drug discovery

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GeneticsbioRxivPreprintJun 16, 2020

Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection

Jin Wei, Mia Madel Alfajaro, Ruth E. Hanna…·Craig B. Wilen

A genome-wide CRISPR screen with SARS-CoV-2 recovers ACE2 and Cathepsin L and nominates SWI/SNF, TGF-beta signalling and HMGB1 as pro-viral; pathway inhibitors blocked virus-induced death.

59 citations

humanexperimental assay

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