Madison S. Strine

This study shows that early-life mucosal T cells promote intestinal stem cell renewal and secretory differentiation through direct interactions and signaling, with impaired function in NEC and adult T cells.

The paper identifies serotonin and related gene expression patterns in human intestinal development using single-cell transcriptomics, revealing cell-type-specific roles in gut development.

The paper uses CRISPR screens to identify mucins as key host factors that restrict SARS-CoV-2 infection in human lung cells.

A genome-wide CRISPR screen with SARS-CoV-2 recovers ACE2 and Cathepsin L and nominates SWI/SNF, TGF-beta signalling and HMGB1 as pro-viral; pathway inhibitors blocked virus-induced death.