Alexis R. Barr

The paper identifies integrin α11 as a quiescence signature protein that promotes cell-cycle re-entry by destabilizing the CDK inhibitor p27 through YAP-dependent regulation.

The paper uses multimodal imaging to show that lysosomes act as a reservoir for PARP inhibitors, leading to heterogeneous drug distribution and response in ovarian cancer.

This study identifies a new role for Wee1 in promoting S-phase entry by inhibiting APC/CCdh1, revealing a mechanism that impacts the efficacy and toxicity of Wee1 inhibitors in cancer treatment.

The paper identifies molecular determinants for phosphotyrosine recognition in tyrosine kinases and shows their roles in tumor promotion and suppression.

The paper identifies mechanisms that prevent innate immune activation by TE-derived cytosolic DNA, preserving pluripotency in ESCs.

This study shows that p21Cip1/Waf1 promotes survival and relapse in TP53 wild-type NSCLC by enabling quiescence and protecting cells from chemotherapy.

This paper shows that dysregulation of CycB:CDK disrupts cell cycle switches, leading to genome doubling, a common event in tumorigenesis.

The paper identifies three interdivision time correlation patterns in cell cycle timing using Bayesian inference on single-cell datasets, revealing hidden rhythmicity and disease-related differences.

This study compares the off-target effects of RNAi, antisense oligonucleotides, and CRISPRi in transcriptomic analyses, showing that all methods have non-negligible off-target effects and recommend using multiple LOF methods for functional validation.