MYC shapes ER-mitochondria calcium transfer by directly targeting ITPR1: implications for MYC-induced safeguard mechanisms and cancer
Xingjie Ma, Athanasios Tsalikis, Mathieu Vernier, Kexin Zhu, Jéhanne El Hassani, Dorian V. Ziegler, Anda Huna, Claire Coquet, Gwladys Revêchon, Céline Margand, Flavie Bénard, Joanna Czarnecka‐Herok, Isabelle Iacono, Catherine Koering, Valéry Attignon, , David Bernard
This study shows MYC regulates ITPR1 to control ER-mitochondria calcium transfer, inducing cell death in normal cells but exploited by cancer cells for survival.
bioRxiv · Aug 28, 2024 · PreprintCancer Biology