Dorian V. Ziegler

CDK4 Restricts Triple-Negative Breast Cancer Cell Migration via Phosphorylation-Driven Activation of Myo9b RhoGAP Function

This study shows CDK4 inhibits TNBC cell migration by phosphorylating Myo9b, which suppresses RhoA signaling, and suggests targeting Myo9b-RhoA could improve CDK4/6 inhibitor therapy.

CDK4 inactivation balances resistance to apoptosis with heightened metabolic sensitivity in triple negative breast cancer cells

This study shows CDK4 inhibition in TNBC cells reduces apoptosis sensitivity and disrupts mitochondrial calcium signaling through MERCs, contributing to resistance to CDK4/6 inhibitors.

MYC shapes ER-mitochondria calcium transfer by directly targeting ITPR1: implications for MYC-induced safeguard mechanisms and cancer

This study shows MYC regulates ITPR1 to control ER-mitochondria calcium transfer, inducing cell death in normal cells but exploited by cancer cells for survival.