Targeting Pre-existing Club-Like Cells in Prostate Cancer Potentiates Androgen Deprivation Therapy
Manon Baurès, Anne-Sophie Vieira Aleixo, Emeline Pacreau, Aysis Koshy, Vanessa Cristina Ribeiro Friedrich, Marc Diedisheim, Martin Raigel, Yichao Hua, Charles Dariane, Florence Boutillon, Lukas Kenner, Jean‐Christophe Marine, Gilles LAVERNY, Daniel METZGER, Florian Rambow, , Vincent Goffin
This study identifies castration-tolerant Club-like cells in prostate cancer and shows that targeting FOSL1/AP-1 and PIM kinases reduces their progenitor properties and tumor growth.
EMBO Molecular Medicine · Feb 2, 2026Peer-reviewedCancer Biology