Author

Jacques‐Emmanuel Guidotti

Centre National de la Recherche ScientifiqueORCID 0000-0001-9285-8167Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Charles DarianeiD· 2 shared Manon Baurès· 2 shared Vincent GoffiniD· 2 shared Anne-Sophie Vieira Aleixo· 1 shared Aysis KoshyiD· 1 shared Daniel METZGERiD· 1 shared Emeline PacreauiD· 1 shared Emilia Puig LombardiiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Charles DarianeORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Targeting Pre-existing Club-Like Cells in Prostate Cancer Potentiates Androgen Deprivation Therapy

Manon Baurès, Anne-Sophie Vieira Aleixo, Emeline Pacreau, Aysis Koshy, Vanessa Cristina Ribeiro Friedrich, Marc Diedisheim, Martin Raigel, Yichao Hua, Charles Dariane, Florence Boutillon, Lukas Kenner, Jean‐Christophe Marine, Gilles LAVERNY, Daniel METZGER, Florian Rambow, , Vincent Goffin

This study identifies castration-tolerant Club-like cells in prostate cancer and shows that targeting FOSL1/AP-1 and PIM kinases reduces their progenitor properties and tumor growth.

EMBO Molecular Medicine · Feb 2, 2026Peer-reviewedCancer Biology

In silico Computed Clusters of Prostate Luminal Progenitors Match FACS-Enriched LSCmed cells

Emilia Puig Lombardi, Manon Baurès, Charles Dariane, Jacques‐Emmanuel Guidotti, Vincent Goffin

The paper re-analyzes scRNA-seq datasets to show that luminal progenitor clusters across studies overlap and matches FACS-enriched LSCmed cells in mice and humans.

bioRxiv · Jun 16, 2021 · PreprintBioinformatics