Time-dependent Mitochondrial Remodeling in Experimental Atrial Fibrillation and Potential Therapeutic Relevance
Xiaoyan Qi, Feng Xiong, Jiening Xiao, Kalai Mangai Muthukumarasamy, Yasemin Altuntaş, Yuan Zhong, Issam Abu-Taha, Florian Bruns, Marcel A. Tekook, Markus Kamler, Louis Robert Villeneuve, Anna Nozza, Martin G. Sirois, Jason M. Karch, Philippe Pasdois, , Stanley Nattel
This study examines mitochondrial changes during atrial fibrillation in animals and humans, showing early hyperfunction and damage, and demonstrates that mitochondrial-targeted therapy can prevent adverse remodeling and AF sustainability.
bioRxiv · Jan 29, 2025 · PreprintPathology