Identification of Functional Genetic Components Modulating Toxicity Response to PFOS using Genome-wide CRISPR Screens in HepG2/C3A cells
Chanhee Kim, Abderrahmane Tagmount, Zhaohan Zhu, Frances Wilson, Danmeng Li, David A. Ostrov, W. Brad Barbazuk, Rhonda L. Bacher, Chris D. Vulpe
This study identifies 340 genes modulating PFOS-induced cytotoxicity in liver cells using CRISPR screens and validates two genes, SLC6A9 and CPSF2, with functional and molecular evidence.
Archives of Toxicology · Jan 27, 2026Peer-reviewedPharmacology & Toxicology