David A. Ostrov

Selective inhibition of respiratory complex I reveals a bioenergetic vulnerability in Francisella

This study identifies respiratory complex I as a selective vulnerability in Francisella and shows that tolfenpyrad inhibits it with species-specific antibacterial activity.

Identification of Functional Genetic Components Modulating Toxicity Response to PFOS using Genome-wide CRISPR Screens in HepG2/C3A cells

This study identifies 340 genes modulating PFOS-induced cytotoxicity in liver cells using CRISPR screens and validates two genes, SLC6A9 and CPSF2, with functional and molecular evidence.

Ancestral origins are associated with SARS-CoV-2 susceptibility and protection in a Florida patient population

This study identifies genetic loci and HLA associations linked to COVID-19 susceptibility in a Florida population, highlighting ancestral differences in disease risk.

Identification of risk and protective human leukocyte antigens in COVID-19 using genotyping and structural modeling

The paper identifies HLA-DPA1 alleles associated with risk and protection from SARS-CoV-2 infection and COVID-19 severity through genotyping and structural modeling.

Molecular docking-based screening for novel inhibitors of the human immunodeficiency virus type 1 protease that effectively reduce the viral replication in human cells

The paper identifies novel HIV-1 protease inhibitors through molecular docking and in vitro testing, showing reduced viral replication and enhanced antiviral activity when combined with Ritonavir.