Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2
Kirsty J. McMillan, Paul James Banks, Francesca LN Hellel, Ruth E. Carmichael, Thomas Clairfeuille, Ashley J. Evans, Kate J. Heesom, Philip A. Lewis, Brett M. Collins, Zafar Iqbal Bashir, Jeremy Martin Henley, Kevin A. Wilkinson, Peter J. Cullen
This study identifies LRFN2 as a new SNX27-dependent cargo that regulates AMPA receptor trafficking and synaptic function, revealing an indirect mechanism for SNX27's role in neurological conditions.
eLife · Jul 12, 2021Peer-reviewedMolecular Biology