Mutant FUS perturbs m6A regulation by repressing ALKBH5, while restoring m6A levels alleviates ALS pathology in vivo
Gaia Di Timoteo, Adriano Setti, Francesca Margarita, Angelo D’Angelo, Andrea Giuliani, Martina Chiara Biagi, Michela Di Salvio, Tiziana Santini, Gianluca Cestra, Irene Bozzoni
This study shows that mutant FUS reduces ALKBH5 expression, increasing m6A levels, and that restoring m6A alleviates ALS pathology in Drosophila models.
bioRxiv · Nov 26, 2025 · PreprintMolecular Biology