Author

Gaia Di Timoteo

Sapienza University of RomeORCID 0000-0003-4516-9945Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Andrea GiulianiiD· 4 shared Irene BozzoniiD· 4 shared Adriano SettiiD· 3 shared Martina Chiara BiagiiD· 3 shared Tiziana SantiniiD· 3 shared Alessia GrandiosoiD· 2 shared Davide MarianiiD· 2 shared Eleonora PeregoiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMolecular Biology

Andrea GiulianiORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Mutant FUS perturbs m6A regulation by repressing ALKBH5, while restoring m6A levels alleviates ALS pathology in vivo

Gaia Di Timoteo, Adriano Setti, Francesca Margarita, Angelo D’Angelo, Andrea Giuliani, Martina Chiara Biagi, Michela Di Salvio, Tiziana Santini, Gianluca Cestra, Irene Bozzoni

This study shows that mutant FUS reduces ALKBH5 expression, increasing m6A levels, and that restoring m6A alleviates ALS pathology in Drosophila models.

bioRxiv · Nov 26, 2025 · PreprintMolecular Biology

A Short 63-Nucleotide Element Promotes Efficient circRNA Translation

Martina Chiara Biagi, Andrea Giuliani, Alessia Grandioso, Gaia Di Timoteo, Irene Bozzoni

This study identifies a 63-nucleotide element that promotes efficient circRNA translation, comparable to traditional IRESs, enhancing their therapeutic potential.

bioRxiv · May 13, 2025 · PreprintMolecular Biology

ALS-associated FUS mutation reshapes the RNA and protein composition of Stress Granules.

Davide Mariani, Adriano Setti, Francesco Castagnetti, Erika Vitiello, Lorenzo Stufera Mecarelli, Gaia Di Timoteo, Andrea Giuliani, Anthony D'Angelo, Tiziana Santini, Eleonora Perego, Sabrina Zappone, Nara Liessi, Andrea Armirotti, Giuseppe Vicidomini, Irene Bozzoni

This study examines how ALS-associated FUS mutations alter the RNA and protein composition of Stress Granules in neural cells, revealing molecular changes linked to neurodegeneration.

Nucleic Acids Research · Oct 29, 2024Peer-reviewedMolecular Biology

M6A reduction relieves FUS-associated ALS granules

Gaia Di Timoteo, Andrea Giuliani, Adriano Setti, Martina Chiara Biagi, Michela Lisi, Tiziana Santini, Alessia Grandioso, Davide Mariani, Francesco Castagnetti, Eleonora Perego, Sabrina Zappone, Serena Lattante, Mario Sabatelli, Dante Rotili, Giuseppe Vicidomini, Irene Bozzoni

The paper shows that reducing m6A content via METTL3 knock-down decreases FUS-associated ALS granules in cell models and patient-derived fibroblasts.

Nature Communications · Jun 12, 2024Peer-reviewedMolecular Biology