Targeting PD-1+ T-cells with Chimeric Antigen Receptors to reduce the HIV Reservoir
Laura Ermellino, Riddhima Banga, Spiros Georgakis, Nicole P. Kadzioch, Francesco A. Procopio, Ana Alcaraz‐Serna, Oscar Alfageme-Abello, Raphaël Porret, Rebecca Cecchin, Michail Orfanakis, Rachel Schelling, Cloé Brenna, Duy-Cat Can, Mathilde Foglierini, Oliver Y. Chén, , Yannick D. Müller
This study designs PD-1-targeting CAR-T-cells to reduce the HIV reservoir by depleting specific T-cell subpopulations in HIV-infected humanized mice.
Science Advances · Apr 24, 2026Peer-reviewedImmunology