The androgen receptor polyglutamine tract sets the transcriptional balance between muscle growth and atrophy
Francis Grafton, Narjes Rohani, Wooi Fang Lim, Yang Kai Ng, Alessandro Fichera, Salma Ali, Virginia Scappini, Alfina A. Speciale, Rebecca Chalcraft, Antonio Garcia-Guerra, Yasumasa Hashimoto, Jennifer Frommer, Maria Pennuto, Esther García Gonzalez, Laura Zanetti-Domingues, , Carlo Rinaldi
This study identifies how the polyglutamine tract in the androgen receptor regulates muscle growth and atrophy by altering transcriptional activity and chromatin binding.
bioRxiv · Sep 30, 2026 · PreprintMolecular Biology