Jennifer Frommer

Cell-resolved pharmacodynamic profiling reveals tissue- and cell-population-specific activity of antisense oligonucleotide chemical conjugates in vivo

This study evaluates cell-specific activity of antisense oligonucleotide conjugates in vivo using a reporter mouse model and finds that palmitate conjugation shows broad extrahepatic activity and preferential skeletal muscle targeting.

The androgen receptor polyglutamine tract sets the transcriptional balance between muscle growth and atrophy

This study identifies how the polyglutamine tract in the androgen receptor regulates muscle growth and atrophy by altering transcriptional activity and chromatin binding.