Author

Alfina A. Speciale

University of OxfordORCID 0000-0001-9728-254XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Matthew J. A. WoodiD· 2 shared Wooi Fang LimiD· 2 shared Alessandro Fichera· 1 shared André GörgensiD· 1 shared Antonio Garcia-GuerraiD· 1 shared Carlo RinaldiiD· 1 shared Christopher Tynan· 1 shared Cláudia C. MendesiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMolecular Biology

Matthew J. A. WoodORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 30, 2026

The androgen receptor polyglutamine tract sets the transcriptional balance between muscle growth and atrophy

Francis Grafton, Narjes Rohani, Wooi Fang Lim…·Carlo Rinaldi

This study identifies how the polyglutamine tract in the androgen receptor regulates muscle growth and atrophy by altering transcriptional activity and chromatin binding.

DOI 10.64898/2026.09.29.755413

humanbulk RNA-seq

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NeuroscienceNature CommunicationsPeer-reviewedNov 18, 2021

GAPDH controls extracellular vesicle biogenesis and enhances therapeutic potential of EVs in silencing the Huntingtin gene in mice via siRNA delivery

Ghulam Hassan Dar, Cláudia C. Mendes, Wei‐Li Kuan…·Matthew J. A. Wood

This study shows GAPDH facilitates EV biogenesis and enables efficient siRNA delivery to the brain, reducing huntingtin gene expression in a mouse model.

100 citationstop 3%

mousebulk RNA-seq

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