A critical role for VE-cadherin in regulating actin dynamics during endothelial maturation and non-inflammatory activation via a tension-sensitive intermediate state
Jonas Franz, Maria Odenthal-Schnittler, Jan Philip Kipcke, Jochen Seebach, Zahra Labbaf, Franziska Merten, Vesna Bojovic, Johannes Andreas Eble, Erez Raz, Milos Galic, Hans‐Joachim Schnittler
The paper identifies a tension-sensitive intermediate state in endothelial cells during non-inflammatory activation, which regulates actin dynamics and barrier function through VE-cadherin and MLC-dephosphorylation.
bioRxiv · Aug 5, 2025 · PreprintCell Biology