Author

G. A. Geest

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Biology Disciplines

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Cancer Biology· 1

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Xu· 1 shared H. Deng· 1 shared H. Yang· 1 shared H. Zhong· 1 shared J. Zhang· 1 shared L. Zhao· 1 shared N. Zamboni· 1 shared P. Dorn· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

D. Xu

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1 paper

Recent·Most cited

A non-canonical function of LDHB promotes SLC7A11-mediated glutathione metabolism and protects against glutaminolysis-dependent ferroptosis in KRAS-driven lung cancer

L. Zhao, H. Deng, J. Zhang, N. Zamboni, G. A. Geest, H. Yang, Z. Yang, Y. Gao, D. Xu, H. Zhong, R. Bruggmann, Q. Zhou, R. A. Schmid, T. Marti, P. Dorn, R.-W. Peng

This study identifies a non-canonical role of LDHB in protecting KRAS-driven lung cancer from ferroptosis by promoting SLC7A11-mediated glutathione metabolism.

bioRxiv · Feb 12, 2023 · PreprintCancer Biology