H. Zhong

Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses

The paper develops methods to image glutamatergic synapses in hippocampal tissue using cryo-electron tomography, enabling high-resolution visualization of synaptic structures.

A 10-valent composite mRNA vaccine against both influenza and COVID-19

This paper introduces FLUCOV-10, a 10-valent mRNA vaccine targeting influenza and SARS-CoV-2, showing robust immune responses and complete protection in mice against multiple strains.

PKA regulation of neuronal function requires the dissociation of catalytic subunits from regulatory subunits

This study shows that PKA catalytic subunits dissociate from regulatory subunits in neurons upon activation, which is necessary for synaptic plasticity and transmission.

BOLA3 and NFU1 link mitoribosome iron-sulfur cluster assembly to multiple mitochondrial dysfunctions syndrome

This study identifies BOLA3 and NFU1 as critical for mitoribosome iron-sulfur cluster assembly, linking their dysfunction to mitochondrial and metabolic disorders.

A non-canonical function of LDHB promotes SLC7A11-mediated glutathione metabolism and protects against glutaminolysis-dependent ferroptosis in KRAS-driven lung cancer

This study identifies a non-canonical role of LDHB in protecting KRAS-driven lung cancer from ferroptosis by promoting SLC7A11-mediated glutathione metabolism.

SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

Nitrogen competition is the general mechanism underlying cnidarian-Symbiodiniaceae symbioses

The paper identifies nitrogen competition as the mechanism controlling cnidarian-Symbiodiniaceae symbioses, showing glucose limits symbiont nitrogen availability while ammonium promotes growth.

Predicting the antigenic evolution of SARS-COV-2 with deep learning

This paper predicts SARS-CoV-2 antigenic evolution using MLAEP, a deep learning model that identifies mutations associated with immune escape and validates them through experiments.

Metabolomic and transcriptomic analyses reveal the effects of grafting on anthocyanin synthesis in grapevine

This study investigates how grafting affects anthocyanin synthesis in grapevines by analyzing metabolomic and transcriptomic profiles across different grafting conditions.

Single snapshot quantitative phase imaging with polarization differential interference contrast

This paper introduces PDIC, a method for single snapshot quantitative phase imaging using a modified DIC microscope and polarization camera, demonstrating its application on biological samples.

High-fidelity, efficient, and reversible labeling of endogenous proteins using CRISPR-based designer exon insertion

The paper introduces CRISPIE, a CRISPR-based method for precise, efficient, and reversible labeling of endogenous proteins by inserting designer exons into target genes.

SARS-CoV-2 manipulates the SR-B1-mediated HDL uptake pathway for its entry

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

Gut microbial communities associated with phenotypically divergent populations of the striped stem borer Chilo suppressalis

The paper examines gut microbial communities in phenotypically divergent populations of Chilo suppressalis, finding variations linked to diet and gut compartments.

Myristoylation alone is sufficient for PKA catalytic subunits to fractionally associate with the plasma membrane to regulate neuronal functions

The paper shows that myristoylation alone can drive membrane association of PKA-C, sufficient for regulating neuronal functions.

A multi-omic cohort as a reference point for promoting a healthy human gut microbiome

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

Dynamic 3D chromosomal landscapes in acute leukemia

The paper examines 3D chromatin changes in T-ALL, identifies TAD fusion events linked to oncogene activation, and shows drug treatments can restore some interactions.

Calorie restriction intervention induces enterotype-associated BMI loss in nonobese individuals

This study shows that calorie restriction leads to BMI loss in nonobese individuals, with variations linked to gut microbiota enterotypes.

Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naïve type 2 diabetics

The paper compares gut metagenomics and metaproteomics in prediabetics and treatment-naïve type 2 diabetics to identify host-microbial interplays across disease stages.

A catalog of microbial genes from the bovine rumen unveils a specialized and diverse biomass-degrading environment

The paper creates a gene catalog of bovine rumen microbes, revealing high diversity and function in plant biomass degradation and methane production.