R. Bruggmann

The lactonase BxdA mediates metabolic adaptation of maize root bacteria to benzoxazinoids

The paper identifies BxdA, a lactonase in maize root bacteria, which enables metabolic adaptation to benzoxazinoids, enhancing bacterial growth under carbon limitation.

CD4+ T cell-derived IL21 regulates stem cell fate in acute myeloid leukemia by activation of p38-MAPK signaling

This study identifies IL21 from CD4+ T cells as a negative regulator of leukemia stem cell self-renewal through ROS and p38-MAPK signaling, with prognostic implications in AML.

A non-canonical function of LDHB promotes SLC7A11-mediated glutathione metabolism and protects against glutaminolysis-dependent ferroptosis in KRAS-driven lung cancer

This study identifies a non-canonical role of LDHB in protecting KRAS-driven lung cancer from ferroptosis by promoting SLC7A11-mediated glutathione metabolism.

Single-cell transcriptomics reveals striking heterogeneity and functional organization of dendritic and monocytic cells in the bovine mesenteric lymph node

The paper uses single-cell transcriptomics to analyze dendritic and monocytic cells in bovine mesenteric lymph nodes, identifying distinct clusters and functional properties.

Extensive diversity and rapid turnover of phage defense repertoires in cheese-associated bacterial communities

The paper analyzes defense mechanisms in cheese-associated bacterial communities, finding rapid turnover of phage defense repertoires and functional CRISPR spacers, but incomplete immunity.

CD8+ T cell priming in oral mucosa-draining lymph nodes supports systemic immunity

This study shows that CD8+ T cells are primed in mandibular lymph nodes after oral Listeria monocytogenes infection, contributing to systemic immunity.

Determination of host cell proteins constituting the molecular microenvironment of coronavirus replicase complexes by proximity-labeling

The paper identifies host proteins near coronavirus replicase complexes using proximity-labeling and shows their roles in viral replication and host processes.

Accumulation of deleterious mutations during bacterial range expansions

This study shows that mutator bacteria accumulate deleterious mutations during range expansion, reducing their fitness, while low mutation rate strains maintain stability.