Author

G. A. Kuhn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 6 Physiology· 6

Signature Assays, Organisms & Methods

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Organism:mouse· 12 Approach:experimental assay· 11 Assay:imaging· 7 Research Focus:cell type annotation· 5 Research Focus:development & morphogenesis· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:clustering· 2

Frequent Co-Authors

E. Wehrle· 8 shared R. Müller· 6 shared A. C. Scheuren· 4 shared G. R. Paul· 4 shared R. Mueller· 4 shared A. Singh· 3 shared S. Hofmann· 3 shared A. Malhotra· 2 shared

Activity by Year

2019-2024 · peak 7/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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8 shared papersBioengineering

E. Wehrle

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12 papers

Recent·Most cited

Daily rhythms in metabolic and locomotor behaviour of prematurely ageing PolgA mice

R. Mueller, A. Singh, G. A. Kuhn, E. Wehrle, D. Yilmaz

This study examines daily metabolic and locomotor rhythms in prematurely ageing PolgA mice, finding sex-specific differences in activity and metabolic patterns.

bioRxiv · Mar 27, 2024Physiology

Unveiling Frailty: Comprehensive and Sex-Specific Characterization in Prematurely Aging PolgA Mice

D. Yilmaz, A. Singh, E. Wehrle, G. A. Kuhn, N. Mathavan, R. Mueller

This study characterizes frailty in PolgA mice, showing sex-specific differences and parallels to human aging.

bioRxiv · Feb 15, 2024Physiology

Trabecular bone remodeling in the ageing mouse: a micro-multiphysics agent-based in silico model using single-cell mechanomics

D. Boaretti, F. C. Marques, C. Ledoux, A. Singh, J. J. Kendall, E. Wehrle, G. A. Kuhn, Y. D. Bansod, F. Schulte, R. Müller

This paper develops an in silico model of trabecular bone remodeling in aging mice, showing how changes in OPG, RANKL, and Scl levels affect bone volume fraction.

bioRxiv · Nov 16, 2022 · PreprintBioengineering

Longitudinal in vivo micro-CT-based approach allows spatio-temporal characterization of fracture healing patterns and assessment of biomaterials in mouse femur defect models

E. Wehrle, D. C. Tourolle né Betts, G. A. Kuhn, E. Floreani, M. H. Nambiar, B. J. Schroeder, S. Hofmann, R. Müller

This study uses longitudinal in vivo micro-CT to analyze fracture healing and assess biomaterials in mouse femur defects, showing collagen scaffolds often fail while BMP-2 improves healing outcomes.

bioRxiv · Oct 2, 2020 · PreprintBioengineering

Individualized cyclic mechanical loading improves callus properties during the remodelling phase of fracture healing in mice as assessed from time-lapsed in vivo imaging

E. Wehrle, G. R. Paul, D. C. Tourolle ne Betts, G. A. Kuhn, R. Müller

This study shows that individualized cyclic mechanical loading during the remodelling phase of fracture healing in mice increases callus formation and mineralization through effects on Wnt-signalling targets.

bioRxiv · Sep 15, 2020Bioengineering

Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect.

A. Malhotra, M. Walle, G. R. Paul, G. A. Kuhn, R. Müller

This study uses real-time finite element analysis to apply adaptive mechanical loading to improve bone healing in a mouse vertebral defect model.

bioRxiv · Sep 13, 2020 · PreprintBioengineering

Effects of early life stress on bone homeostasis in mice and humans

K. Wuertz-Kozak, M. Roszkowski, E. Cambria, A. Block, G. A. Kuhn, T. Abele, W. Hitzl, D. Driesslein, R. Mueller, M. Rapp, I. M. Mansuy, E. M. J. Peters, P. M. Wippert

This study examines the effects of early life stress on bone homeostasis in mice and humans, finding catabolic bone changes associated with stress-related factors.

bioRxiv · Jul 21, 2020Physiology

Mechano-regulation of bone adaptation is controlled by the local in vivo environment and logarithmically dependent on loading frequency

A. C. Scheuren, P. Vallaster, G. A. Kuhn, G. R. Paul, A. Malhotra, Y. Kameo, R. Müller

This study investigates how bone adapts to mechanical loading by analyzing the relationship between loading frequency and bone volume fraction changes, finding a logarithmic dependency.

bioRxiv · May 15, 2020Physiology

Effects of long-term in vivo micro-CT imaging on hallmarks of osteopenia and frailty in aging mice

A. C. Scheuren, G. A. Kuhn, R. Müller

This study assesses the impact of long-term in vivo micro-CT imaging on aging markers in mice, finding small but significant changes in bone morphology without genotype-specific effects.

bioRxiv · May 10, 2020Physiology

Hallmarks of frailty and osteosarcopenia in prematurely aged PolgAD257A/D257A mice

A. C. Scheuren, G. D'Hulst, G. A. Kuhn, E. Masschelein, E. Wehrle, K. De Bock, R. Müller

This study evaluates PolgA(D257A/D257A) mice as a model for frailty and osteosarcopenia, showing accelerated health deficits and musculoskeletal deterioration compared to wild-type mice.

bioRxiv · Feb 14, 2020Physiology

The association between mineralised tissue formation and the mechanical local in vivo environment: Time-lapsed quantification of a mouse defect healing model

D. Tourolle ne Betts, E. Wehrle, G. R. Paul, G. A. Kuhn, P. Christen, S. Hofmann, R. Muller

This study uses time-lapsed imaging to show that local mechanical strains correlate with mineralised tissue formation in a mouse bone defect model.

bioRxiv · Nov 18, 2019Bioengineering

Evaluation of longitudinal time-lapsed in vivo micro-CT for monitoring fracture healing in mouse femur defect models

E. Wehrle, D. C. Tourolle ne Betts, G. A. Kuhn, A. C. Scheuren, S. Hofmann, R. Mueller

This study evaluates longitudinal in vivo micro-CT for monitoring fracture healing in mice, finding no significant impact on callus formation or remodeling from repeated scans.

bioRxiv · Oct 17, 2019Bioengineering