S. Hofmann

Non-invasive optoacoustic imaging visualizes exercise-induced dermal revascularization in obese mice

The paper uses optoacoustic imaging to monitor microvascular changes in obese mice during exercise, showing improved vascular density and oxygenation in adipose tissues.

Culture system for longitudinal monitoring of bone remodeling ex vivo

This study develops an ex vivo culture system with longitudinal micro-CT scanning to monitor bone remodeling in osteochondral explants, revealing enhanced bone formation under dynamic compression.

Integration of Osteoclastogenesis through addition of PBMCs in Human Osteochondral Explants cultured Ex vivo

This study shows that adding PBMCs to human osteochondral explants enhances osteoclast activity and resorption, suggesting the need for external osteoclast precursors in long-term bone remodeling cultures.

A dialysis medium refreshment cell culture set-up for an osteoblast-osteoclast coculture

This study develops a dialysis-based cell culture system for osteoblast-osteoclast cocultures, showing increased osteoblastic and osteoclastic activity compared to standard methods.

Towards bone-remodeling-on-a-chip: self-assembling 3D osteoblast-osteoclast coculture in a microfluidic chip

This paper presents a 3D microfluidic coculture model of human bone remodeling using osteoblasts and osteoclasts, enabling long-term in vitro studies for drug testing.

Towards development of serum substitute medium to induce osteoclast differentiation of human peripheral blood derived monocytes

This paper develops a serum substitute medium to support osteoclast differentiation from human peripheral blood monocytes, achieving all functional markers after 21 days of culture.

Matrix vesicle isolation from a three-dimensional in vitro bone model

This study isolates and characterizes matrix vesicles from a 3D in vitro bone model, showing they resemble natural matrix vesicles and could be used for bone regeneration.

The impact of culture variables on 3D human in vitro bone remodeling; a design of experiments approach

This study evaluates how culture variables affect in vitro human bone remodeling models using a design of experiments approach to improve reproducibility and translatability.

Development of serum substitute medium for bone tissue engineering

This study develops a serum substitute medium for bone tissue engineering that performs as well as fetal bovine serum in cell attachment, survival, and matrix deposition under mechanical stress.

Characterization of three-dimensional bone-like tissue growth and organization under influence of curvature and directional fluid flow

This study evaluates how curvature and directional fluid flow affect three-dimensional bone-like tissue growth and organization using human mesenchymal stromal cells in a concave channel scaffold.

Fasting-sensitive SUMO-switch on Prox1 controls hepatic cholesterol metabolism

This study shows that SUMOylation of Prox1 regulates hepatic cholesterol metabolism in response to fasting, with implications for metabolic health.

Evaluating material-driven regeneration in a tissue engineered human in vitro bone defect model

This study develops an in vitro human bone defect model to evaluate material-driven regeneration using tissue engineering, observing vascular-like network growth and bone-like tissue formation.

Tuning the resorption-formation balance in an in vitro 3D osteoblast-osteoclast co-culture model of bone

This study tunes an in vitro 3D osteoblast-osteoclast co-culture model to simulate bone formation, resorption, and equilibrium states using different culture media and monocyte seeding densities.

Bioinspired Silk Fibroin Mineralization for Advanced In Vitro Bone Remodeling Models

This study develops a bioinspired silk fibroin-based scaffold for in vitro bone remodeling that supports osteoclast and osteoblast interactions, reducing animal experiments and advancing drug testing for osteoporosis.

Human Platelet Lysate as Alternative of Fetal Bovine Serum for Enhanced Human in vitro Bone Resorption and Remodeling

This study compares fetal bovine serum (FBS) and human platelet lysate (hPL) as supplements in in vitro bone remodeling models, finding hPL supports both osteoclast and osteogenic differentiation with concentration-dependent effects.

Alkaline phosphatase activity of serum affects osteogenic differentiation cultures

This study shows that alkaline phosphatase activity in fetal bovine serum affects mineral deposition and osteogenic differentiation in cell cultures.

Osteoblast-osteoclast co-cultures: a systematic review and map of available literature

This study systematically reviews osteoblast-osteoclast co-culture studies to provide databases for methods, outcomes, and parameters, enabling comparison and validation of research.

Relict groups of spiny frogs indicate Late Paleogene-Early Neogene trans-Tibet dispersal of thermophile faunal elements

This study uses genetic data from spiny frogs to infer Late Paleogene-Early Neogene dispersal patterns across the Himalaya-Tibet orogen, supporting trans-Tibet migration of thermophilic species.

Functional multispectral optoacoustic tomography imaging of hepatic steatosis development in mice

This study uses MSOT to non-invasively visualize lipid accumulation in mice with NAFLD, showing its potential for monitoring hepatic steatosis without contrast agents.

Longitudinal in vivo micro-CT-based approach allows spatio-temporal characterization of fracture healing patterns and assessment of biomaterials in mouse femur defect models

This study uses longitudinal in vivo micro-CT to analyze fracture healing and assess biomaterials in mouse femur defects, showing collagen scaffolds often fail while BMP-2 improves healing outcomes.

An Organoid for woven Bone

This study develops a 3D in vitro organoid model of woven bone formation using human bone marrow stromal cells, demonstrating osteoblast and osteocyte co-culture and mineralization.

Scaffold pore geometry guides gene regulation and bone-like tissue formation in dynamic cultures

This study shows that scaffold pore geometry and dynamic mechanical cues influence osteoblast differentiation and bone-like tissue formation in vitro.

Rewinding the molecular clock in the genus Carabus (Coleoptera: Carabidae) in light of fossil evidence and the Gondwana split: a re-analyses.

This paper reanalyzes the molecular clock dating of the genus Carabus using fossil evidence and the Gondwana split, finding significantly older divergence times than previous studies.

The association between mineralised tissue formation and the mechanical local in vivo environment: Time-lapsed quantification of a mouse defect healing model

This study uses time-lapsed imaging to show that local mechanical strains correlate with mineralised tissue formation in a mouse bone defect model.

Evaluation of longitudinal time-lapsed in vivo micro-CT for monitoring fracture healing in mouse femur defect models

This study evaluates longitudinal in vivo micro-CT for monitoring fracture healing in mice, finding no significant impact on callus formation or remodeling from repeated scans.