This study uses single-cell RNA sequencing and spatial transcriptomics to characterize the muscle microenvironment in PAD, identifying altered endothelial diversity and LYVE1+ macrophage activation.

bioRxiv · Jun 21, 2023Cell Biology

IL-6 SIGNALING EXACERBATES HALLMARKS OF CHRONIC TENDON DISEASE BY STIMULATING REPARATIVE FIBROBLASTS

T. Stauber, G. Moschini, A. A. Hussien, P. K. Jaeger, K. De Bock, J. G. Snedeker

This study identifies IL-6 signaling as a driver of chronic tendon disease by activating reparative fibroblasts and promoting tendinopathy hallmarks.

bioRxiv · Feb 13, 2023Bioengineering

The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions

Z. Fan, R. Ardicoglu, A. Batavia, R. Rust, L. von Ziegler, R. Waag, J. Zhang, T. Desgeorges, O. Sturman, H. Dang, R. Weber, A. E. Moor, M. E. Schwab, P.-L. Germain, J. Bohacek, K. De Bock

This study shows that Apold1 is not essential for normal angiogenesis but is critical for revascularization under ischemic conditions and tumor growth.

bioRxiv · Dec 2, 2022 · PreprintCell Biology

MME+ fibro-adipogenic progenitors are the dominant adipogenic population during fatty infiltration in human skeletal muscle

G. Fitzgerald, G. Turiel, T. Gorski, I. Soro-Arnaiz, J. Zhang, N. C. Casartelli, E. Masschelein, N. A. Maffiuletti, R. Sutter, M. Leunig, J. Farup, K. De Bock

The paper identifies MME+ fibro-adipogenic progenitors as the main adipogenic population in fatty infiltrated human skeletal muscle using single-cell RNA sequencing.

bioRxiv · Apr 22, 2022Cell Biology

Creatine transporter deficient rat model show motor dysfunction, cerebellar alterations and muscle creatine deficiency without muscle atrophy

L. Duran-Trio, G. Fernandes-Pires, J. Grosse, I. Soro-Arnaiz, C. Roux-Petronelli, P.-A. Binz, K. De Bock, C. Cudalbu, C. Sandi, O. Braissant

bioRxiv · Oct 12, 2021Pathology

Exercise promotes satellite cell contribution to myofibers in a load-dependent manner

E. Masschelein, G. D'Hulst, J. Zvick, L. C. Hinte, I. Soro-Arnaiz, T. Gorski, F. von Meyenn, O. Bar-Nur, K. De Bock

This study shows that mechanical load during exercise promotes satellite cell contribution to myofibers, independent of fiber type and hypertrophy.

bioRxiv · Mar 19, 2020Cell Biology

Hallmarks of frailty and osteosarcopenia in prematurely aged PolgAD257A/D257A mice

A. C. Scheuren, G. D'Hulst, G. A. Kuhn, E. Masschelein, E. Wehrle, K. De Bock, R. Müller

This study evaluates PolgA(D257A/D257A) mice as a model for frailty and osteosarcopenia, showing accelerated health deficits and musculoskeletal deterioration compared to wild-type mice.

bioRxiv · Feb 14, 2020Physiology