D. Shibata

Growth Dynamics of Ductal Carcinoma in Situ Recapitulate Normal Breast Development

This study reconstructs DCIS growth dynamics using somatic mutation topography, revealing a multiclonal, branching morphogenesis-like pattern consistent with a new Comet model of tumorigenesis.

Testing Adaptive Therapy Protocols using Gemcitabine and Capecitabine on a Mouse Model of Endocrine-Resistant Breast Cancer

This study tests adaptive therapy protocols using gemcitabine and capecitabine on a mouse model of endocrine-resistant breast cancer, finding improved survival with adaptive strategies over high-dose combination therapy.

Phenotypic plasticity and genetic control in colorectal cancer evolution

This study investigates phenotypic plasticity and genetic control in colorectal cancer by analyzing gene expression and genetic variation across multiple tumor regions.

The co-evolution of the genome and epigenome in colorectal cancer

This study examines the co-evolution of genome and epigenome in colorectal cancer using single-clone spatial multi-omic profiling, revealing epigenetic changes and their impact on mutation accumulation.

Gattaca: Base pair resolution mutation tracking for somatic evolution studies using agent-based models

Gattaca generates base-pair resolution artificial genomes to track somatic mutations in agent-based models, enabling in-silico studies comparable to human somatic evolution.

Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic data

This study uses spatial multiomic data to assess the evolutionary impact of putative driver mutations in colorectal cancer, identifying both genetic and non-genetic factors influencing subclonal expansion.

Negative selection may cause grossly altered but broadly stable karyotypes in metastatic colorectal cancer

This study analyzes longitudinal genomic data from colorectal cancer patients to show that negative selection stabilizes karyotypes during tumor progression and metastasis.

Minimal Barriers to Invasion During Human Colorectal Tumor Growth

The paper examines intra-tumoral heterogeneity in colorectal tumors and finds that early multiclonal invasion occurs with minimal barriers to invasion.

How Homeostasis Limits Keratinocyte Evolution

This study presents a mechanistic epidermal model showing homeostasis leads to log-linear subclone size distributions in skin cells, with larger subclones being older due to persistence of driver mutations.