Author

G. Chenevix-Trench

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

F. Al-Ejeh· 3 shared J. Beesley· 3 shared W. Shi· 3 shared A. Civitarese· 2 shared A. E. McCart Reed· 2 shared D. Black· 2 shared J. D. French· 2 shared J. M. Saunus· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

F. Al-Ejeh

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The potential of Senicapoc, a KCNN4 inhibitor, for the prevention and treatment of breast cancer

G. Chenevix-Trench, K. Britt, C. Xiao, M. Miranda, W. Shi, J. Beesley, J. Saunus, A. Civitarese, D. Black, M. Ruppert, M. Perreira, S. Jackson, Z. Teale, D. Carter-Cusack, L. Kalinowski, , F. Al-Ejeh

This study investigates Senicapoc, a KCNN4 inhibitor, and finds it delays mammary tumor development and slows tumor growth in mouse models, suggesting potential for breast cancer prevention and treatment.

bioRxiv · Apr 25, 2023 · PreprintCancer Biology

CRISPR screens identify gene targets and drug repositioning opportunities at breast cancer risk loci

N. K. Tuano, J. Beesley, M. Manning, W. Shi, L. Malver-Ortega, J. Paynter, D. Black, A. Civitarese, K. McCue, A. Hatzipantelis, K. Hillman, S. Kaufmann, H. Sivakumaran, J. M. Polo, R. Reddel, , J. Rosenbluh

bioRxiv · Sep 7, 2021 · PreprintCancer Biology

Epigenome erosion drives neural crest-like phenotypic mimicry in triple-negative breast cancer and other SOX10+ malignancies

J. M. Saunus, X. M. De Luca, K. Northwood, A. Raghavendra, A. Hasson, A. E. McCart Reed, M. Lim, S. Lal, A. C. Vargas, J. R. Kutasovic, A. J. Dalley, M. Miranda, E. Kalaw, P. Kalita-de Croft, I. Gresshoff, , S. R. Lakhani

The paper identifies SOX10 expression in TNBC and other SOX10+ malignancies, linking it to epigenome erosion and neural crest-like phenotypic mimicry through promoter hypomethylation.

bioRxiv · Mar 30, 2021 · PreprintCancer Biology

A short ERK5 isoform modulates nucleocytoplasmic shuttling of active ERK5 and associates with poor survival in breast cancer

M. S. Miranda, J. M. Saunus, S. Akgül, M. Moradi Marjaneh, J. R. Kutasovic, W. Shi, O. Chatterjee, F. Casciello, E. Rozali, H. Y. Handoko, A. P. Wiegmans, T. Liu, J. S. Lee, B. W. Day, S. Edwards, , F. Al-Ejeh

This paper identifies a short ERK5 isoform that promotes extranuclear localization of active ERK5, driving EMT and poor survival in breast cancer.

bioRxiv · Mar 23, 2021Cancer Biology