G. Di Venanzio

Replicative Acinetobacter baumannii strains interfere with phagosomal maturation by modulating the vacuolar pH

This study shows that clinical Acinetobacter baumannii strains evade macrophage degradation by preventing phagosome acidification through ammonia secretion.

InvL, an invasin-like adhesin, is a type II secretion system substrate required for Acinetobacter baumannii uropathogenesis.

This paper identifies InvL, a type II secretion system effector in Acinetobacter baumannii, as an adhesin required for urinary tract infection.

Modern Acinetobacter baumannii clinical isolates replicate inside spacious vacuoles and egress from macrophages

This study shows modern A. baumannii clinical isolates replicate inside macrophage vacuoles and escape via lysis, unlike older lab strains.

Plasmid-encoded H-NS controls extracellular matrix composition in a modern Acinetobacter baumannii urinary isolate

This study shows that plasmid-encoded H-NS in Acinetobacter baumannii represses extracellular matrix components, reducing biofilm formation and virulence.

The glycoprotease CpaA secreted by medically relevant Acinetobacter species targets multiple O-linked host glycoproteins

This paper identifies CpaA, a glycoprotease from Acinetobacter species, as a broad-spectrum enzyme that cleaves multiple O-linked human glycoproteins, including those involved in complement activation, and proposes its use in glycoproteomics.

Peptidoglycan editing provides immunity to Acinetobacter baumannii during bacterial warfare

Acinetobacter baumannii incorporates D-Lysine into its peptidoglycan to gain immunity against T6SS attacks from competitors, though this trait is lost in pathogenic strains due to host enzyme activity.