Molecular mode of action of an Acyl Protein thioesterase
L. Abrami, M. Audagnotto, S. Ho, M. J. Marcaida, F. Mesquita, M. Anward, P. A. Sandoz, G. Fonti, F. Pojer, M. Dal Peraro, F. G. van der Goot
The paper investigates the molecular mechanism of APT2, showing it interacts with membranes via a hydrophobic loop and S-acylation, deforms lipid bilayers to extract acyl chains, and is subject to ubiquitination and degradation.
bioRxiv · Jun 18, 2020 · PreprintCell Biology