The Ebola virus VP40 matrix undergoes endosomal disassembly essential for membrane fusion
S. L. Winter, G. Golani, F. Lolicato, M. Vallbracht, K. Thiyagarajah, S. S. Ahmed, C. Luechtenborg, O. T. Fackler, B. Bruegger, T. Hoenen, W. Nickel, U. S. Schwarz, P. Chlanda
This study shows that Ebola virus VP40 matrix disassembles in endosomes due to pH changes, facilitating membrane fusion and viral entry.
bioRxiv · Aug 24, 2022 · PreprintMicrobiology