U. S. Schwarz

Modelling Cell Shape in 3D Structured Environments: A Quantitative Comparison with Experiments

This paper compares different computational models for predicting 3D cell shapes in structured environments with experimental data, finding that a linear area energy Hamiltonian performs best.

Grand canonical Brownian dynamics simulations of adsorption and self-assembly of SAS-6 rings on a surface

The paper uses simulations to study SAS-6 ring self-assembly on surfaces, finding that weak interactions and small angular ranges favor nine-fold symmetry.

The role of hydrodynamic flow in the self-assembly of dragline spider silk proteins

This study investigates how hydrodynamic flow influences the self-assembly of spider silk proteins through molecular and coarse-grained simulations, revealing flow-induced conformational changes and assembly dynamics.

The Ebola virus VP40 matrix undergoes endosomal disassembly essential for membrane fusion

This study shows that Ebola virus VP40 matrix disassembles in endosomes due to pH changes, facilitating membrane fusion and viral entry.

Force propagation between epithelial cells depends on active coupling and mechano-structural polarization

This study shows that force propagation between epithelial cells depends on active coupling and mechano-structural polarization, with stronger responses when polarization is perpendicular to force direction.

Nonmuscle myosin IIA dynamically guides regulatory light chain phosphorylation and assembly of nonmuscle myosin IIB

The paper investigates the dynamic roles of nonmuscle myosin IIA and IIB in regulating minifilament assembly and force generation through phosphorylation and co-assembly mechanisms.

Superresolution microscopy reveals partial preassembly and subsequent bending of the clathrin coat during endocytosis

The paper uses superresolution microscopy to show clathrin coats partially assemble on flat membranes before bending, and introduces a model to explain this process.

A particle-based computational model to analyse remodelling of the red blood cell cytoskeleton during malaria infections

The paper develops a particle-based computational model to simulate red blood cell cytoskeleton remodeling during malaria infection, showing how actin mining and KAHRP clustering affect mechanical properties and protein distribution.

KAHRP dynamically relocalizes to remodeled actin junctions and associates with knob spirals in P. falciparum-infected erythrocytes

This study uses super-resolution microscopy to show KAHRP relocalizes to remnant actin junctions and associates with spiral scaffolds in P. falciparum-infected erythrocytes.

Asynchronous nuclear cycles in multinucleated Plasmodium falciparum enable rapid proliferation

The paper shows that Plasmodium falciparum nuclei replicate DNA asynchronously, leading to heterogeneous progeny numbers and slower replication during overlapping events.

Distinct roles of nonmuscle myosin II isoforms for establishing tension and elasticity during cell morphogenesis

This study investigates the distinct roles of nonmuscle myosin II isoforms in cell morphogenesis by analyzing their contributions to tension and elasticity using CRISPR/Cas9 knockouts and mathematical modeling.

Surface-catalyzed SAS-6 self-assembly directs centriole formation through kinetic and structural mechanisms

This study identifies two physical principles governing centriole formation through surface-catalyzed SAS-6 self-assembly and structural conversion.

Electrostatic and bending energies predict staggering and splaying in nonmuscle myosin II minifilaments

The paper uses electrostatics and elasticity theory to predict dynamic behaviors of nonmuscle myosin II minifilaments, showing parallel staggers lead to splaying and stable antiparallel staggers initiate nucleation.

Optogenetic Control of RhoA Reveals Zyxin-mediated Elasticity of Stress Fibers

This study uses optogenetic RhoA control to show that zyxin regulates stress fiber elasticity, revealing how localized RhoA activation drives actin flow and traction forces in fibroblasts.