Author

O. T. Fackler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:CITE-seq· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

P. Chlanda· 3 shared L. Zimmermann· 2 shared R. Bartenschlager· 2 shared A. Imle· 1 shared A. Ruggieri· 1 shared A. Savarino· 1 shared A. T. Ayoub· 1 shared B. Bruegger· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMicrobiology

P. Chlanda

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A tissue-intrinsic mechanism sensitizes HIV-1 particles for TLR-triggered innate immune responses

S. Sid Ahmed, L. Zimmermann, A. Imle, K. Wuebben, N. Tibroni, L. Rauch-Wirth, J. Muench, P. Chlanda, F. Graw, O. T. Fackler

The paper identifies a tissue-intrinsic mechanism where the extracellular matrix restricts HIV-1 infectivity and enhances innate immune detection through conformational changes in viral Env and TLR recognition.

bioRxiv · Nov 22, 2023Immunology

A General Method to Accurately Count Molecular Complexes and Determine the Degree of Labelling in Cells Using Protein Tags

S. A. Tashev, J. Euchner, K. Yserentant, S. Hänselmann, F. Hild, W. Chmielewicz, J. Hummert, F. Schwörer, N. Tsopoulidis, S. Germer, Z. Sassmannshausen, O. T. Fackler, U. Klingmüller, D.-P. Herten

This paper introduces ProDOL, a method to measure degree of labelling in cells using protein tags, and applies it to study HIV-1 Nef's effect on CD4 T cell activation.

bioRxiv · Sep 8, 2023 · PreprintCell Biology

ediTONSIL: Activation-Neutral Gene Editing of CD4 T cells in Human ex Vivo Tonsil Cultures

K. Morath, L. Sadhu, G. Dyckhoff, M. Gapp, O. T. Keppler, O. T. Fackler

The paper introduces ediTONSIL, a method to edit resting CD4 T cells from human tonsil tissue without activation, achieving >90% knockout efficacy and preserving cell function.

bioRxiv · Aug 21, 2023 · PreprintImmunology

The Ebola virus VP40 matrix undergoes endosomal disassembly essential for membrane fusion

S. L. Winter, G. Golani, F. Lolicato, M. Vallbracht, K. Thiyagarajah, S. S. Ahmed, C. Luechtenborg, O. T. Fackler, B. Bruegger, T. Hoenen, W. Nickel, U. S. Schwarz, P. Chlanda

This study shows that Ebola virus VP40 matrix disassembles in endosomes due to pH changes, facilitating membrane fusion and viral entry.

bioRxiv · Aug 24, 2022 · PreprintMicrobiology

Temporal control of the integrated stress response by a stochastic molecular switch

P. Klein, S. M. Kallenberger, H. Roth, K. Roth, T. B. N. Ly-Hartig, V. Magg, J. Ales, S. Rastgou Talemi, Y. Qiang, S. Wolf, O. Oleksiuk, R. Kurilov, B. Di Ventura, R. Bartenschlager, R. Eils, , A. Ruggieri

The paper identifies a stochastic molecular switch controlling the integrated stress response through cooperative activation of PKR, ultrasensitive eIF2 phosphorylation, and negative feedback via GADD34.

bioRxiv · Jan 1, 2022Cell Biology

The FDA-approved drug cobicistat synergizes with remdesivir to inhibit SARS-CoV-2 replication

I. L. Shytaj, M. Fares, B. Lucic, L. Gallucci, M. M. Tolba, L. Zimmermann, A. T. Ayoub, M. Cortese, C. J. Neufeldt, V. Laketa, P. Chlanda, O. T. Fackler, S. Boulant, R. Bartenschlager, M. Stanifer, , M. Lusic

This study shows that cobicistat synergizes with remdesivir to inhibit SARS-CoV-2 replication in cell lines and organoids, reducing viral replication to levels comparable to uninfected cells.

bioRxiv · Mar 9, 2021Microbiology