Author

J. J. Milner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:mouse· 4 Approach:statistical model· 4 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

C. Toma· 3 shared A. J. Getzler· 2 shared A. W. Goldrath· 2 shared B. Mcdonald· 2 shared B. P. Riesenberg· 2 shared H. Diao· 2 shared J. E. Thaxton· 2 shared J. Kim· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

C. Toma

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Epithelial organoid supports resident memory CD8 T cell differentiation

M. Ulibarri, Y. Lin, J. R. Ramprashad, G. Han, M. H. Hasan, F. J. Mithila, C. Ma, S. Gopinath, N. Zhang, J. J. Milner, L. Beura

This paper develops a murine vaginal epithelial organoid system that supports CD8 T cell differentiation into resident memory T cells in vitro, showing phenotypic and transcriptional similarity to in vivo TRM.

bioRxiv · Dec 1, 2023Immunology

Adaptive IRE1 Signaling Elicits T Cell Metabolic Remodeling and Tumor Control

B. P. Riesenberg, E. J. Gandy, A. S. Kennedy, E. G. Hunt, K. E. Hurst, E. L. Sedlacek, P. Gao, M. J. Emanuele, J. Modliszewski, J. M. Green, J. J. Milner, L. Wiseman, J. E. Thaxton

This study shows that enhancing the adaptive IRE1 UPR pathway in T cells improves tumor control by reducing mitochondrial toxicity and chronic ER stress.

bioRxiv · Nov 16, 2023 · PreprintImmunology

Mll1 pioneers histone H3K4me3 deposition and promotes formation of CD8+ T stem cell memory

A. J. Getzler, M. A. Frederick, J. J. Milner, T. Venables, H. Diao, C. Toma, S. Nagaraja, D. Albao, S. Belanger, S. M. Tsuda, J. Kim, S. Crotty, A. Goldrath, M. E. Pipkin

This study identifies Mll1 as a key factor in establishing CD8+ T stem cell memory by promoting H3K4me3 deposition and regulating Pol II elongation during TCR stimulation.

bioRxiv · Jan 18, 2023 · PreprintImmunology

Atlas-Guided Discovery of Transcription Factors for T Cell Programming

H. K. Chung, C. Liu, A. Battu, A. N. Jambor, B. M. Pratt, F. Xie, B. P. Riesenberg, E. Casillas, M. Sun, E. Landoni, Y. Li, Q. Ye, D. Joo, J. Green, Z. Syed, , S. M. Kaech

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

bioRxiv · Jan 3, 2023Immunology

Single-cell lineage trajectories and chromatin regulators that initialize antiviral CD8 T cell ontogeny

H. Diao, R. Chen, S. M. Tsuda, D. Wang, M. A. Frederick, J. Kim, P. P. Karunadharma, G. J. Martinez, A. J. Getzler, C. Toma, J. J. Milner, T. C. Venables, D. M. Martin, A. W. Goldrath, S. Crotty, M. E. Pipkin

The paper defines single-cell trajectories and identifies chromatin regulators that establish antiviral CD8 T cell heterogeneity during acute and chronic infections.

bioRxiv · Aug 11, 2021 · PreprintImmunology

Functional delineation of tissue-resident CD8 T cell heterogeneity during infection and cancer

J. J. Milner, C. Toma, Z. He, N. S. Kurd, Q. P. Nguyen, B. McDonald, L. Quezada, C. E. Widjaja, D. A. Witherden, J. T. Crowl, G. W. Yeo, J. T. Chang, K. D. Omilusik, A. W. Goldrath

This study identifies distinct CD8+ T cell subsets in non-lymphoid tissues during infection and cancer, revealing their functional roles and regulatory mechanisms.

bioRxiv · Mar 5, 2020 · PreprintImmunology

Engineering bacteriocin-mediated resistance against plant pathogenic bacteria in plants

W. M. Rooney, R. Grinter, A. Correia, J. Parkhill, D. Walker, J. J. Milner

This paper demonstrates that expressing the bacteriocin putidacin L1 in plants provides effective resistance against Pseudomonas syringae and related pathogens.

bioRxiv · May 24, 2019 · PreprintPlant Biology