A. W. Goldrath

This study shows that transcription factors maintain CD8+ T cell naivety by enforcing a distinct chromatin architecture that remodels upon activation.

The paper defines single-cell trajectories and identifies chromatin regulators that establish antiviral CD8 T cell heterogeneity during acute and chronic infections.

The paper characterizes CD8+ T cell responses to SARS-CoV-2 across HLA alleles, showing HLA genotype influences pre-existing immunity and immune repertoire upon viral exposure.

This study investigates the role of Usp1 in regulating Id2 and Id3 proteins in T cells, showing its impact on memory cell maintenance and secondary immune responses.

This study identifies a terminally differentiated effector memory CD8 T cell population with unique molecular and functional properties that challenge classical definitions of effector memory cells.

This study identifies distinct CD8+ T cell subsets in non-lymphoid tissues during infection and cancer, revealing their functional roles and regulatory mechanisms.