G. Jacquemin

Leishmania infantum-exploited Nrf2 transcription factor as a virulence process to escape macrophage-driven ferroptosis-like leishmanicidal process

This study identifies Nrf2 as a key factor in Leishmania infantum infection by protecting macrophages from ferroptosis-like cell death, suggesting it as a therapeutic target for visceral leishmaniasis.

In vivo imaging of mammary epithelial cell dynamics in response to lineage-biased Wnt/Beta-catenin activation

This study uses in vivo imaging to show that Wnt/Beta-catenin activation in mammary epithelial lineages leads to hyperplastic lesions and squamous transdifferentiation.

Longitudinal high-resolution imaging through a flexible intravital imaging window

This study presents a versatile, fully flexible imaging window that acts as an implantable transparent second skin for small laboratory animal in vivo imaging.

Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme

This study identifies THBS1-YAP signaling as a paracrine mechanism that reprograms healthy intestinal epithelial cells to support tumor growth.

Lineage tracing of Notch1-expressing cells in intestinal tumours reveals a distinct population of cancer stem cells.

The paper identifies Notch1-expressing cells in intestinal tumors as a distinct population of cancer stem cells with properties similar to intestinal stem cells but reduced Lgr5 expression.