Author

L. Mourao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. L. Scheele· 2 shared J. Jonkers· 2 shared A. Bongaarts· 1 shared A. Bruna· 1 shared A. De Jaime-Soguero· 1 shared A. L. Zeeman· 1 shared A. P. Nikolakopoulos· 1 shared A. Pabba· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

C. L. Scheele

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Chemotherapy-treated breast cancer cells activate the Wnt signaling pathway to enter a diapause-DTP state.

F. Lluis, Y. Ellaithy, W. A. Abreu de Oliveira, A. Pabba, A. Qualizza, F. Richard, P. Athanasouli, C. R. Luci, W. De Wispelaere, L. Mourao, S. Hamer, S. Moens, A. De Jaime-Soguero, M. Francesca Baietti, S. J. Hutten, , D. Annibali

This study shows chemotherapy induces a Wnt-active diapause-DTP state in breast cancer cells, which can be targeted by combined Wnt and chemotherapy inhibition.

bioRxiv · Mar 8, 2024 · PreprintCancer Biology

An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade

D. Houbaert, A. P. Nikolakopoulos, O. Mece, K. Jacobs, J. Roels, G. Shankar, M. Agrawal, S. More, M. Ganne, K. Rillaerts, L. Boon, M. Swoboda, M. Nobis, L. Mourao, F. M. Bosisio, , P. Agostinis

This study shows that autophagy in lymphatic endothelial cells controls T cell egress from lymph nodes, which is critical for immune checkpoint therapy effectiveness.

bioRxiv · Jul 17, 2023Immunology

Annexin A1 is a polarity cue that directs planar mitotic spindle orientation during mammalian epithelial morphogenesis

M. Fankhaenel, F. S. Golestan Hashemi, L. Mourao, E. Lucas, M. M. Hosawi, P. Skipp, X. Morin, C. L. Scheele, S. Elias

This study identifies Annexin A1 as a polarity cue that directs planar mitotic spindle orientation in mammalian epithelial cells by regulating LGN and NuMA cortical anchoring.

bioRxiv · Jul 28, 2021 · PreprintCell Biology

Hyperactive WNT/CTNNB1 signaling induces a competing cell proliferation and epidermal differentiation response in the mouse mammary epithelium

L. Mourao, A. L. Zeeman, K. E. Wiese, A. Bongaarts, L. L. Oudejans, I. Mora Martinez, Y. B. C. van de Grift, J. Jonkers, R. van Amerongen

This study investigates the effects of hyperactive WNT/CTNNB1 signaling in mouse mammary epithelium, showing it induces competing proliferation and differentiation responses depending on signaling levels.

bioRxiv · Jun 22, 2021 · PreprintCancer Biology

Lineage tracing of Notch1-expressing cells in intestinal tumours reveals a distinct population of cancer stem cells.

L. Mourao, G. Jacquemin, M. Huyghe, W. J. Nawrocki, N. Menssouri, N. Servant, S. Fre

The paper identifies Notch1-expressing cells in intestinal tumors as a distinct population of cancer stem cells with properties similar to intestinal stem cells but reduced Lgr5 expression.

bioRxiv · Jul 9, 2018Cancer Biology