Author

L. Lefevre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

A. Coste· 3 shared E. Meunier· 2 shared K. Santoni· 2 shared R. Planes· 2 shared A. B. Lawrence· 1 shared A. Baeri· 1 shared A. Boyance· 1 shared A. Carminati· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

A. Coste

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Leishmania infantum-exploited Nrf2 transcription factor as a virulence process to escape macrophage-driven ferroptosis-like leishmanicidal process

A. Coste, C. Blot, K. Coulson, M. Salon, M. Tertrais, R. Planes, K. Santoni, H. Authier, G. Jacquemin, M. Rahabi, M. Parny, I. Raymond-Letron, E. Meunier, L. Lefevre

This study identifies Nrf2 as a key factor in Leishmania infantum infection by protecting macrophages from ferroptosis-like cell death, suggesting it as a therapeutic target for visceral leishmaniasis.

bioRxiv · Sep 15, 2023 · PreprintMicrobiology

Stem cell-derived macrophages as a new platform for studying host-pathogen interactions in livestock

S. Meek, T. Watson, L. Eory, G. McFarlane, F. J. Wynne, S. McCleary, L. E. M. Dunn, E. M. Charlton, C. Craig, B. Shih, T. Regan, R. M. Taylor, L. Sutherland, A. Gossner, C. Chintoan-Uta, , T. Burdon

The paper uses stem cell-derived macrophages from livestock to study host-pathogen interactions, showing they can be infected by important viruses and genetically modified.

bioRxiv · Sep 10, 2021Immunology

Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-induced phenotypic plasticity and resistance in melanoma

S. Diazzi, A. Baeri, J. Fassy, M. Lecacheur, O. Marin-Bejar, C. Girard, L. Lefevre, C. Lacoux, M. Irondelle, C. Mounier, M. Truchi, M. Couralet, A. Carminati, I. Berestjuk, F. Larbret, , S. Tartare-Deckert

This study identifies the miR-143/-145 cluster as a driver of therapy-resistant mesenchymal-like phenotype in melanoma and shows that blocking its pro-fibrotic effects enhances MAPK inhibitor efficacy.

bioRxiv · Jul 2, 2021Cancer Biology

Phospholipid peroxidation fuels ExoU phospholipase-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology

S. Bagayoko, S.-A. Leon-Icaza, M. Pinilla, A. Hessel, K. Santoni, P.-J. Bordignon, F. Moreau, E. Eren, A. Boyance, E. Naser, L. Lefevre, C. Berrone, N. Iacobachvili, A. Metais, Y. Rombouts, , E. Meunier

This study identifies phospholipid peroxidation as a mechanism enhancing ExoU phospholipase activity, leading to cell necrosis and supporting Pseudomonas aeruginosa pathogenesis.

bioRxiv · Feb 17, 2021Immunology

Mesenchymal stromal cells release CXCL1/2/8 and induce chemoresistance and macrophage polarization

B. Couderc, A. Le Naour, M. Prat, R. Mevel, B. Thibault, L. Lemaitre, H. Leray, M. Golzio, L. Lefevre, E. Mery, A. Martinez, G. Ferron, J.-P. Delord, A. Coste

This study identifies CXCL1/2/8 as factors released by cancer-associated mesenchymal stromal cells that induce chemoresistance and macrophage polarization, suggesting CXCR1/2 inhibition as a potential therapeutic strategy.

bioRxiv · Dec 4, 2018 · PreprintCancer Biology