Author

G. Kritikos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:E. coli· 3 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

M. Banzhaf· 4 shared A. F. Cunningham· 2 shared A. L. Lovering· 2 shared A. Mateus· 2 shared A. Typas· 2 shared I. T. Cadby· 2 shared M. M. Savitski· 2 shared R. W. Meek· 2 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersMicrobiology

M. Banzhaf

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structure-function characterization of the conserved regulatory mechanism of the Escherichia coli M48 metalloprotease BepA

J. A. Bryant, I. T. Cadby, Z.-S. Chong, Y. R. Sevastsyanovich, F. C. Morris, A. F. Cunningham, G. Kritikos, R. W. Meek, M. Banzhaf, S.-S. Chng, A. L. Lovering, I. R. Henderson

The paper presents the crystal structure of E. coli BepA, an M48 metalloprotease, and shows that its active site plug regulates function and is conserved across the family.

bioRxiv · Jul 30, 2020Microbiology

Phage proteins block and trigger retron toxin/antitoxin systems

J. Bobonis, K. Mitosch, A. Mateus, G. Kritikos, J. R. Elfenbein, M. M. Savitski, H. Andrews-Polymenis, A. Typas

The paper identifies phage proteins that block or trigger retron toxin/antitoxin systems in bacteria, revealing their role in anti-phage defense.

bioRxiv · Jun 22, 2020 · PreprintMicrobiology

Structure-function analysis of the Escherichia coli β-barrel assembly enhancing protease BepA suggests a role for a self-inhibitory state

J. Bryant, I. T. Cadby, Z.-S. Chong, Y. Sevastsyanovich, F. Morris, A. F. Cunningham, G. Kritikos, R. W. Meek, M. Banzhaf, S.-S. Chng, I. Henderson, A. L. Lovering

This study presents the crystal structure of BepA, a protease involved in LptD folding, and shows its auto-regulation and role in maintaining outer membrane lipid asymmetry.

bioRxiv · Jul 2, 2019 · PreprintMicrobiology

Biofilm inhibitor taurolithocholic acid alters colony morphology, specialized metabolism, and virulence of Pseudomonas aeruginosa

A. R. Condren, L. J. Kahl, G. Kritikos, M. Banzhaf, L. E. P. Dietrich, L. M. Sanchez

This study shows that taurolithocholic acid inhibits Pseudomonas aeruginosa biofilm formation and alters its specialized metabolism and virulence.

bioRxiv · Jun 20, 2019Microbiology

The outer membrane lipoprotein NlpI nucleates hydrolases within peptidoglycan multi-enzyme complexes in Escherichia coli

M. Banzhaf, H. C. L. Yau, J. Verheul, A. Lodge, G. Kritikos, A. Mateus, A. K. Hov, F. Stein, M. Wartel, M. Pazos, A. S. Solovyova, M. M. Savitski, T. den Blaauwen, A. Typas, W. Vollmer

This study identifies NlpI as a scaffold for PG hydrolases in E. coli, forming multi-enzyme complexes that coordinate PG synthesis and hydrolase activity.

bioRxiv · Apr 16, 2019Microbiology