G. Lajoie

HR3/RORα-mediated cholesterol sensing regulates TOR signaling

The paper identifies HR3/RORα as a conserved cholesterol sensor that activates the TOR pathway in Drosophila and human cells, linking cholesterol availability to growth regulation.

Experimental exposure to winter thaws reveals tipping point in yellow birch bud mortality and phenology in the northern temperate forest of Quebec, Canada

The paper tests how winter thaws affect yellow birch bud phenology and mortality under climate warming scenarios, finding a tipping point where frequent thaws delay phenology and increase mortality.

Data-driven identification of major axes of functional variation in bacteria

This paper identifies major axes of functional variation in bacteria using genomic and metagenomic data, showing that evolutionary history shapes bacterial distribution across ecosystems.

ADAM protease inhibition overcomes resistance of breast cancer stem-like cells to γδ T cell immunotherapy

This study identifies ADAM protease inhibition as a strategy to overcome resistance of breast cancer stem-like cells to γδ T cell immunotherapy by blocking MICA shedding.

Drivers of phyllosphere microbial functional diversity in a neotropical forest

This study quantifies bacterial functional diversity in the phyllosphere of 17 neotropical tree species using metagenomic sequencing, showing that host traits and phylogeny influence microbial function and that 16S-based functional predictions are less accurate than metagenomic data.