Author

G. M. Siegers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

I. Dutta· 3 shared J. Liu· 3 shared J. Schueler· 3 shared D. Dieters-Castator· 2 shared L. M. Postovit· 2 shared L.-M. Postovit· 2 shared A. A. Ojeda· 1 shared A. B. Bukhari· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

I. Dutta

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

L-DOS47 enhances response to immunotherapy in pancreatic cancer tumor

B. V. Jardim-Perassi, P. Irrera, D. Abrahams, V. C. Estrella, B. Ordway, S. R. Byrne, A. A. Ojeda, C. J. Whelan, J. Kim, M. S. Beatty, S. Damgaci-Erturk, D. L. Longo, K. J. Gaspar, G. M. Siegers, B. A. Centeno, , A. Ibrahim-Hashim

This study shows that L-DOS47, a urease immunoconjugate, enhances anti-PD1 immunotherapy efficacy in pancreatic cancer by neutralizing tumor acidity.

bioRxiv · Aug 28, 2023 · PreprintCancer Biology

Targeted Proteomics of Plasma Extracellular Vesicles Uncovers MUC1 as Combinatorial Biomarker for the Early Detection of High-grade Serous Ovarian Cancer

T. T. Cooper, D. Z. Dieters-Castator, J. Liu, G. M. Siegers, L. Veliz, D. Pink, J. D. Lewis, Y. Fu, F. Lagugne-Labarthet, H. Steed, G. A. Lajoie, L. M. Postovit

bioRxiv · Mar 31, 2022Cancer Biology

Docosahexaenoic acid significantly reduces tumor cell growth in preclinical models of ovarian cancer

O. Bilyk, B. Hamedi, I. Dutta, M. Newell, A. B. Bukhari, A. M. Gamper, R. C. McVea, J. Liu, J. Schueler, G. M. Siegers, C. J. Field, L.-M. Postovit

This study shows that docosahexaenoic acid (DHA) enhances the anti-cancer effects of carboplatin in ovarian cancer models, reducing tumor growth and improving survival.

bioRxiv · Nov 10, 2020Cancer Biology

ADAM protease inhibition overcomes resistance of breast cancer stem-like cells to γδ T cell immunotherapy

I. Dutta, D. Dieters-Castator, J. W. Papatzimas, A. Medina, J. Schueler, D. J. Derksen, G. Lajoie, L. M. Postovit, G. M. Siegers

This study identifies ADAM protease inhibition as a strategy to overcome resistance of breast cancer stem-like cells to γδ T cell immunotherapy by blocking MICA shedding.

bioRxiv · Jul 17, 2020Immunology

Translational control of breast cancer plasticity

M. Jewer, L. Lee, G. Zhang, J. Liu, S. D. Findlay, K. M. Vincent, K. Tandoc, D. Dieters-Castator, D. F. Quail, I. Dutta, M. Coatham, Z. Xu, B.-J. Guan, M. Hatzoglou, A. Brumwell, , L.-M. Postovit

The paper identifies hypoxia and drug-induced translational activation of NANOG, SNAIL, and NODAL isoforms that drive breast cancer plasticity and stem-cell-like phenotypes, with potential therapeutic implications.

bioRxiv · Apr 2, 2019Cancer Biology