M. R. Larsen

Growth factor-induced desialylation for the fast control of endocytosis

The paper shows that growth factors induce rapid desialylation of cell surface glycoproteins, enabling reversible changes in glycan structure and function through galectin-mediated endocytosis.

HR3/RORα-mediated cholesterol sensing regulates TOR signaling

The paper identifies HR3/RORα as a conserved cholesterol sensor that activates the TOR pathway in Drosophila and human cells, linking cholesterol availability to growth regulation.

Angiotensin-(1-5) is a Potent Endogenous Angiotensin AT2-Receptor Agonist

This study identifies angiotensin-(1-5) as a potent endogenous agonist of the AT2-receptor, showing its ability to increase nitric oxide release and lower blood pressure through AT2R-mediated mechanisms.

The protein map of the protozoan parasite Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis and Leishmania (Leishmania) infantum during growth phase transition and temperature stress

This study analyzes the proteomes of three Leishmania species under different growth phases and temperature stress to identify molecular changes during parasite-host interactions.

Leishmaniinae: evolutionary inferences based on protein expression profiles (PhyloQuant) congruent with phylogenetic relationships among Leishmania, Endotrypanum, Porcisia, Zelonia, Crithidia, and Leptomonas

The paper infers evolutionary relationships among Leishmaniinae parasites using protein expression profiles, finding results congruent with established DNA-based phylogeny.

Off-targets of BRAF inhibitors disrupt endothelial signaling and differentially affect vascular barrier function

This study investigates off-target effects of BRAF inhibitors on endothelial cells, revealing differential impacts on vascular barrier function and signaling.

Enrichment of Cysteine S-palmitoylation using Sodium Deoxycholate Acid Precipitation - SDC-ACE

The paper introduces SDC-ACE, a method to enrich S-palmitoylated peptides, and applies it to study S-palmitoylation in mouse brain and tissues, revealing its role in diabetes and obesity.

Blockade of redox second messengers inhibits JAK/STAT and MEK/ERK signaling sensitizing FLT3-mutant acute myeloid leukemia to targeted therapies

This study identifies the Rac-NOX2 complex as a driver of redox signaling in FLT3-mutant AML, showing that inhibiting NOX2 reduces key signaling pathways and enhances response to FLT3 inhibitors.

Systems-wide analysis of glycoprotein conformational changes by limited deglycosylation assay

The paper introduces a new method called LDA to analyze glycoprotein conformational changes on a systems-wide scale and demonstrates its application in detecting structural changes under ER stress.

The phosphoproteome of rice leaves responds to water and nitrogen supply

This study investigates how water and nitrogen supply affect the phosphoproteome of rice leaves, identifying phosphorylation changes in proteins related to membrane transport and metabolic processes.

Increasing proteome coverage using cysteine-specific DIA Mass spectrometry - Cys-DIA

The paper introduces Cys-DIA, a DIA mass spectrometry method that enhances proteome coverage by 35% in cancer cell lines with different metastatic abilities.

Phosphoproteomic identification of Xin as a novel requirement for skeletal muscle disuse atrophy

This study identifies Xin as a novel protein involved in skeletal muscle disuse atrophy using phosphoproteomic analysis and confirms its regulation in mice and humans.

CImP: Cellular Imprinting Proteomics applied to ocular disorders elicited by Congenital Zika virus Syndrome

The paper introduces CImP, a proteomics method for analyzing ocular surface cells in infants with and without Congenital Zika Syndrome, identifying molecular changes linked to ZIKV exposure.

Simultaneous proteomics and three PTMomics characterization of pro-inflammatory cytokines stimulated INS-1E cells using TiO2 enrichment strategy

This paper introduces a mass spectrometry-based strategy called TiCPG to simultaneously analyze proteome and three PTMs in cytokine-stimulated INS-1E cells, revealing extensive PTM regulation in beta-cell apoptosis pathways.