G. Lamberet

(p)ppGpp/GTP and malonyl-CoA modulate Staphylococcus aureus adaptation to FASII antibiotics and provide a basis for synergistic bi-therapy

This paper shows that (p)ppGpp and malonyl-CoA modulate S. aureus adaptation to FASII antibiotics, and that combining a (p)ppGpp inducer with an anti-FASII drug blocks bacterial outgrowth.

Permissive Fatty Acid Incorporation in Host Environments Promotes Staphylococcal Adaptation to FASII Antibiotics

This study shows that Staphylococcus aureus can adapt to FASII antibiotics by incorporating environmental fatty acids in host conditions, challenging the assumption of fatty acid stringency.