Genome-wide CRISPR/Cas9 screen identifies MAT2A as a critical host factor for BK Polyomavirus
L. Caller, S. Ho, K. Brown, L. Dupont, T. Zaletel, R. Beale, P. J. Lehner, C. M. Crump
The paper identifies MAT2A as a critical host factor for BKPyV infection through a CRISPR/Cas9 screen and shows a small molecule inhibitor of MAT2A is a potent antiviral drug.
bioRxiv · Oct 20, 2023 · PreprintMicrobiology