(p)ppGpp/GTP and malonyl-CoA modulate Staphylococcus aureus adaptation to FASII antibiotics and provide a basis for synergistic bi-therapy
A. Pathania, J. Anba-Mondoloni, M. Gominet, D. Halpern, J. Dairou, L. Dupont, G. Lamberet, P. Trieu-Cuot, K. Gloux, A. Gruss
This paper shows that (p)ppGpp and malonyl-CoA modulate S. aureus adaptation to FASII antibiotics, and that combining a (p)ppGpp inducer with an anti-FASII drug blocks bacterial outgrowth.
mBio · Feb 23, 2021Peer-reviewedMicrobiology