Author

G. Mantus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Assay:proteomics· 4 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Wrammert· 5 shared L. Lai· 4 shared M. E. Davis-Gardner· 4 shared R. Ahmed· 4 shared V. V. Edara· 4 shared A. Chandele· 3 shared A. Sharma· 3 shared C. W. Davis· 3 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

J. Wrammert

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5 papers

Recent·Most cited

Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response

A. Patel, S. Kumar, L. Lai, C. Chakravarthy, R. Valanparambil, E. S. Reddy, K. Gottimukkala, P. Bajpai, D. R. Raju, V. V. Edara, M. E. Davis-Gardner, S. Linderman, K. Dixit, P. Sharma, G. Mantus, , E. A. Ortlund

The paper identifies three monoclonal antibodies that poorly neutralize the Omicron BA.1 variant, revealing structural and molecular features of antibody evasion.

bioRxiv · Oct 24, 2022Immunology

Structural insights for neutralization of BA.1 and BA.2 Omicron variants by a broadly neutralizing SARS-CoV-2 antibody

S. Kumar, A. Patel, L. Lai, C. Chakravarthy, R. Valanparambil, M. E. Davis-Gardner, V. V. Edara, S. Linderman, E. S. Reddy, K. Gottimukkala, K. Nayak, P. Bajpai, V. Singh, F. Frank, N. Cheedarla, , A. Chandele

This paper identifies and structurally analyzes an antibody that neutralizes SARS-CoV-2 BA.1 and BA.2 variants, revealing its unique epitope and mechanism of action.

bioRxiv · May 13, 2022Immunology

mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 Omicron variant

V.-V. Edara, K. E. Manning, M. Ellis, L. Lai, K. M. Moore, S. L. Foster, K. Floyd, M. E. Davis-Gardner, G. Mantus, L. E. Nyhoff, S. Bechnack, G. Alaaeddine, A. Naji, H. Samaha, M. Lee, , M. S. Suthar

This study evaluates the neutralizing activity of mRNA vaccines against the SARS-CoV-2 Omicron variant, showing reduced efficacy after the second dose but improved responses following a third dose.

bioRxiv · Dec 20, 2021Immunology

Reduced binding and neutralization of infection- and vaccine-induced antibodies to the B.1.351 (South African) SARS-CoV-2 variant

V. V. Edara, C. Norwood, K. Floyd, L. Lai, M. E. Davis-Gardner, W. H. Hudson, G. Mantus, L. E. Nyhoff, M. W. Adelman, R. Fineman, S. Patel, R. Byram, D. N. Gomes, G. Michael, H. Abdullahi, , M. S. Suthar

The paper compares antibody binding and neutralization against SARS-CoV-2 B.1 and B.1.351 variants in infected and vaccinated individuals, finding reduced titers but retained neutralization.

bioRxiv · Feb 20, 2021 · PreprintImmunology

Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India

K. Nayak, K. Gottimukkala, S. Kumar, E. S. Reddy, V. V. Edara, R. Kauffman, K. Floyd, G. Mantus, D. Savargaonkar, P. K. Goel, S. Arora, M. Rahi, C. W. Davis, S. Linderman, J. Wrammert, , A. Chandele

This study examines humoral and memory B cell responses in Indian COVID-19 recovered individuals, finding that RBD-specific IgG correlates with neutralizing antibodies and can serve as a surrogate for neutralization assays.

bioRxiv · Aug 31, 2020Immunology